ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

AuBE Study

Autonomic Baby Evaluation (AuBE) study may be a prospective observational follow-up of a single-center cohort to assess during a population of consecutive term and preterm newborns the most effect of the autonomic maturation profile during the primary two years of life on psychometric development assessed at 3 years. Normative data at each stage of sleep should be defined with this longitudinal study that needs a posh and careful analysis of cardiac and electroencephalographic physiological signals.While a dysfunction of the autonomic systema nervosum (ANS) determined from the cardio-respiratory rhythms in children may represent a key criteria within the physiopathology of possible neurodevelopmental disorders, the traditional thresholds and profile of the ANS maturation during the 2 first years of life haven't been established.he Autonomic Baby Evaluation (AuBE) study may be a prospective observational prospective single-center cohort following a population of 302 consecutive term and preterm newborns.   The primary objective of the “AuBE” prospective cohort is to define the autonomic systema nervosum maturity profile obtained, during the 2 first years of life, by repeated polysomnography and 24-hour ECG recordings, with a duration values for every autonomic indices of interest and therefore the secondary objective is to work out , the potential influence of this autonomic profile, on sleep disorders and on cognitive development at the age of three . Parental questionnaires on sleep quality of youngsters and mood status of the mother are collected at birth and at 6, 12, 18 and 24 months (i.e. M0, M6, M12, M18 and M24). A psychometric status is measured at 3 years for all children.      

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