Abstract

Comparison of CT findings of between MDR-TB and XDR-TB: A propensity score matching study

Author(s): Hyejin Cheon*

Purpose: The purpose of this study was to compare the CT findings between MDR-TB and XDR-TB groups using by propensity score matching.

Materials and methods: This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent was waived. From October 2008 to March 2016, 72 MDR-TB patients and 25 XDR-TB were enrolled in this study. A 2:1 MDR-TB group/XDR-TB group matching was done by using propensity score matching. Computed Tomography (CT) findings and demographic factors were compared before and after propensity score matching.


Results: After propensity matching, 50 MDR-TB patients and (mean age, 42.9 ± 6.1 [standard deviation]; age range, 46-91 years) 25 XDR-TB patients (mean age, 44.4 ± 9.7 [standard deviation]; age range, 36-77 years) were included this study after 2:1 propensity score matching. Before matching, among independent variables for propensity matching, the anti-tuberculous treatment history was significantly different between two groups (p=0.017). After matching, statistically significant radiologic finding between MDR- and XDR-TB were the cavity wall thickness (P<0.001) and cavity size (P=0.041). The mean thickness of cavities was 8.0 mm in MDR-TB group and 11.5 mm in XDR-TB group respectively. The mean size of cavities was 21 mm in MDR-TB group and 36 mm in XDR-TB group, respectively. Other CT findings were not significantly different between two groups.

Conclusion: The cavity wall thickness and size of cavity were significantly different between MDR-TB and XDR-TB groups after 2:1 propensity score matching.