Diabetes mellitus is a metabolic disorder, which is characterized by chronic hyperglycemia and disturbances of the metabolism of carbohydrate, fat and protein that resulted due to defects in insulin secretion, action or both of them. People with diabetes are prone to increased risk of many diseases, such as cardiac, peripheral arterial and cerebrovascular disease. There are many people with diabetes that refuse to take their medication such as insulin or synthetic drugs to reduce and control their raised blood glucose level. They depend on, when they eat much sweetness food, take their medication. So, this commentary discusses some of the complications of uncontrolled diabetes mellitus and their relation with cardiovascular disease.